Requested to bat first, Australia by no means recovered from slipping from 20-0 to 88-6, with Cooper Connolly retiring harm due to a suspected damaged hand after being struck by Mohammad Hasnain.
Sean Abbott top-scored 30, whereas six batters failed to achieve double figures.
“Our complete batting line-up actually did not get going in any respect all through the sequence,” stated captain Josh Inglis.
Pakistan openers Saim Ayub and Shafique placed on 84 for the primary wicket earlier than captain Rizwan and Babar Azam wrapped up a 2-1 sequence win.
Australia received the primary ODI by two wickets and Pakistan the second by 9 wickets.
They start a three-match T20 sequence beginning on Thursday in Brisbane.